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They also lose their sterile coating, making each subsequent injection more uncomfortable than the last

Other strategies to increase the delivery of drugs across BBB, particularly monoclonal antibodies, that are currently under development include bi-specific antibodies (a group that included the above-mentioned LRP-1 and other receptor-mediated transporters), nanoparticles (including liposomes, metallic nanoparticles and dendrimers), exosomes, viral vectors (Pardridge, 2015)