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Effect of GLP-1 receptor agonist on ischemia reperfusion injury in rats with metabolic syndrome
Note that high-dose biotin supplements (often marketed for hair health) can interfere with laboratory test results, including thyroid function tests and cardiac markers
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The Wayne State / Brooklyn College work does not build on those in vivo results directly, but the two papers together suggest the transdermal route is reproducibly reaching the tissue layer that matters, at least in preclinical conditions
