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Adiposity & Body Composition Animal and clinical trial datasets describe substantial reductions in fat mass over 24- and 48-week protocols, with investigators attributing the magnitude to combined incretin and glucagon-receptor effects on intake and expenditure

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Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have been pivotal for obesity treatment, achieving 1525 % weight loss over 1224 months, but questions remain about the potential influence of concomitant losses in muscle mass