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Basic science experiments demonstrated weight-independent immunomodulatory effects of GLP-1 analogs through inhibition of the NF-B pathway (via AMP-activated protein kinase phosphorylation in psoriasis and prevention of IB phosphorylation in rheumatoid arthritis), the researchers wrote

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doi: 10.1111/cea.12860 48 DokkenBBLa BonteLRDavis-GormanGTeacheyMKSeaverNMcDonaghPF
Glucagon-like-peptide-1 receptor agonist, like native glucagon-like peptide-1, Exendin-4, and Liraglutide, exert context-, dose-, and timing-dependent effects on human mesenchymal stem cells
