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Liraglutide improved nociceptive thresholds and mitigated histopathological damage of the sciatic nerve in a rat model of diabetic neuropathy induced by nicotinamide and streptozotocin [46]

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In the brain, preproglucagon expressing neurons are localized to the brainstem in regions including the nucleus of the solitary tract (NTS) and ventrolateral medulla (Merchenthaler et al., 1999) and these neurons produce a number of peptides including GLP-1, oxyntomodulin, and glucagon-like peptide-2 (Holst, 2007)

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