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According to a 2023 study, about 1% of Ozempic users and 0.7% of Saxenda users developed stomach paralysis, compared to 0.3% of those taking Contrave

Subsequent administration of the GLP-1 receptor agonist semaglutide (Sem) to dams in late pregnancy revealed a modest decrease in maternal food intake during initial treatment

Lancet 394(10193):121130

He noted that the 4 mg dose achieved "nearly 20% weight loss with one escalation step," while the 12 mg dose "delivered a level of weight loss long associated with bariatric surgery." He added that retatrutide could support a more patient-centric approach to treating obesity