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Therefore, potent, short-acting DPP-IV inhibitors taken at meal time might provide brief stimulation of insulin secretion by increasing levels of insulinotropic GLP-1 (7-36) amide, allowing escape from DPP-IV inhibition and the intermittent production of insulinomimetic GLP-1 (9-36) amide during interprandial periods

The innovation potential is compelling

They found that patients using exenatide once weekly reported a significant increase in treatment satisfaction from baseline compared with exenatide twice daily, despite similar adherence rates (98%) between the two groups

These needle-free alternatives could offer a simpler, more accessible way for people to benefit from GLP-1 therapy