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Downstream interaction by glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide agonism is required for synergistic effects on body weight
Reduced adipose tissue changes how estrogen, testosterone, and other hormones are metabolized

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Some people who were previously struggling to lose weight on GLP-1 therapy alone find that addressing their depression with bupropion unlocks the lifestyle changes needed for the medication to work as intended
