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Week 12: Appetite Starts To Shrink Patients often notice feeling less hungry after 7 to 14 days

Clinicians working in eating disorder settings have begun documenting this pattern

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30 , 32 Owing to the 1 week PK halflife of semaglutide, Santi 32 recently used PK simulations to show that oncemonthly dosing requires very high dose sizes to maintain drug concentrations above a presumed therapeutic threshold