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doi: 10.1016/j.tibs.2009.02.004
Volcano plot visualization of GLP-1MK-801 relative to vehicle revealed transcripts associated with glutamatergic signalling, such as Grin2a , Grin2b , Shisa6 and Slc17a7 among the most differentially upregulated genes (Fig
Antidiabetic medications included insulin (n=21), metformin (n=19), sodium-glucose cotransporter 2 (SGLT2) inhibitors (n=5) and dipeptidyl peptidase 4 (DPP-4) inhibitors (n=1)
This provides evidence that cardiovascular benefits from GLP-1R agonism may also come from metabolic changes in cardiac tissue through systemic signaling (Almutairi et al
