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Description
This review explores the therapeutic potential of GLP-1 RAs in AS, summarising pre-clinical and clinical data and elucidating the pathways through which GLP-1 RAs might offer renoprotective benefits
A renal ultrasound revealed no stones or masses, and the recent use of tirzepatidewas identified
* BRET : Bioluminescence resonance energy transfer BSA : Bovine serum albumin CyOFP : Cyan-excitable orange fluorescent protein DERET : Diffusion-enhanced resonance energy transfer FCS : Fluorescence correlation spectroscopy FITC : Fluorescein isothiocyanate GFP : Green fluorescent protein GLP-1(R)(A) : Glucagon-like peptide-1 (receptor) (agonist) GUV : Giant unilameller vesicle MCD : Methyl--cyclodextrin Nb37 : Nanobody-37 POPC : 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine T2D : Type 2 diabetes TMR : Tetramethylrhodamine TR-FRET : Time-resolved Frster resonance energy transfer
By blocking GDF-8 before its release, this mechanism offers high selectivity and fewer side effects
