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How it may feel: Tingling or itching at the site Increased redness compared to previous injections Heightened discomfort when the skin is touched In addition to sensitivity, other GLP-1 skin side effects may include: Dryness or irritation around injection areas Hives or allergic reactions (rare but serious) Discoloration or texture changes, if injections are repeatedly given in the same spot If skin sensitivity worsens or reactions spread, your healthcare provider may suggest adjusting techniques, switching medications, or using different needle sizes