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First description in humans of the ability of SGLT2 inhibitors to attenuate glomerular hyperfiltration, likely by affecting tubuloglomerular feedback mechanisms

Given the substantial cost burden on plan sponsors, it will be crucial to see how effective these programs are at improving long-term cardiometabolic health and reducing downstream complications, justifying the investment and potentially sustaining coverage

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Strengths include comprehensive coverage of pharmacokinetics, safety, mechanistic insights, and health system considerations