generic names for glp-1 drugs Removing the needle: the unmet need oral GLP-1 GLP-1s Like Ozempic May Be

doi: 10.7326/0003-4819-142-6-200503150-00010

Its difficult to distinguish direct anti-inflammatory effects from the benefits of weight loss and improved metabolic health, but the pattern is consistent enough to warrant further study. A 2025 study found that RA patients with a BMI over 27 taking GLP-1 medications showed improvements in symptoms and disease activity

GLP-1R triggers various intracellular signaling pathways, such as the cAMP/PKA and PI3K/Akt pathways, by binding to endogenous GLP-1 or exogenous agonists, resulting in the enhancement of insulin secretion, inhibition of glucagon secretion, as well as anti-inflammatory and antioxidant stress response

Ongoing and future largescale randomized trials will be critical for clarifying efficacy and safety for this use