do glp 1 have long term effects of use Clinical Recommendations to Manage Gastrointestinal Adverse Events in Patients The GLP-1 Trap: Your Jumpstart

When starting semaglutide, injection tracking and side effect logging are very important

GLP-1 receptor activation stimulates glucose-dependent insulin secretion, suppresses glucagon release, and slows gastric emptying in research models GIP receptor activation potentiates insulin secretion and modulates adipose tissue metabolism in preclinical studies Glucagon receptor partial agonism supports hepatic glucose output modulation and increased energy expenditure at physiological concentrations in research models The simultaneous engagement of all three receptors produces coordinated effects on insulin secretion, glucagon suppression, energy expenditure, and metabolic signaling studied in preclinical models and referenced in peer-reviewed literature

Obesity 31, 703715

In summary, glucose uptake into the L-cells seems to be mediated via both, GLUT2 and SGLT1 (Figure 3) [[274], [275], [276]], with the electrogenic SGLT1 mediated uptake being of particular importance for stimulus secretion coupling