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To investigate which transporters are involved in the transport of metformin across the apical surface of enterocytes, Han et al used pharmacological inhibitors and knockdown studies in single transporter-expressing CHO (Chinese hamster ovary) cells and Caco-2 cell monolayers [20]
The FDA required a black box warning on the drugs label due to the risk of thyroid tumors in animal studies, and this warning continues to shape how the drug is prescribed and monitored
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TRIUMPH-4 identified dysesthesia (changes in skin sensation) as a new safety signal not observed in Phase 2 trials
