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The GIP receptor pathway, popularized by tirzepatide's dual agonist approach, adds another layer of metabolic optimization through its effects on both glucose homeostasis and lipid metabolism

Both hypoglycemia and the adjustment period as glucose levels normalize can cause tiredness

centrally-mediated loss of appetite & increased thermogenic activity GLP-1 receptors are found in regions of the hindbrain and hypothalamus that regulate feeding behavior Centrally mediated GLP-1 effects include: reduction of food intake - resulting in weight loss due to reduced caloric intake activation of sympathetic pathways in the dorsomedial hypothalamus (DMH) and ventromedial nucleus of the hypothalamus (VMH) that increase neuronally mediated thermogenic activity of brown adipose tissue (BAT) resulting in increased energy expenditure with associated weight loss (Contreras et al, 2017

Hydrogel-based microneedles have high drug loading capacity and responsive release in preclinical models