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Results As described in Figures 1 and 2, a total of 2,232 articles were found in an initial Medline search, of which 846 articles were regarding GLP-1RA and 1,386 articles were related to SGLT2-I

Defective design: Claims assert that the drug itself is inherently unsafe in its intended use

In contrast, another study in rats demonstrated that acute injection of the GLP-1R agonist exendin-4 (Ex-4) increases baseline glucose levels in rats which is due to the activation of the sympathetic nervous system (Perez-Tilve et al., 2010)

The increase in cAMP levels in -cells is a consequence of GLP-1R activation in these cells, which in turn enhances the secretion of growth inhibitory hormone through signaling pathways such as PKA and Calcium/Calmodulin-dependent protein kinase (Strowski et al., 2000