tirzepatide needs prescription vs. Semaglutide: Which Weight Loss Medication Is Right for You? Mounjaro (tirzepatide): Uses, Side Effects,

Things are different now that they're both taking an obesity drug

The TRIUMPH-4 trial protocol provides the best reference for effective dosing : Weeks 1-4: 2 mg once weekly (starting dose) Weeks 5-8: 4 mg once weekly Weeks 9-12: 6 mg once weekly Weeks 13-16: 8 mg once weekly Week 17+: 9 mg or 12 mg once weekly (maintenance dose) The escalation happens every 4 weeks, which is slightly faster than many tirzepatide protocols

Some people feel appetite suppression at 2.5mg, but the clinical trials showed that meaningful weight loss begins at 5mg and increases with each dose escalation up to 15mg

JAMA 331 , 384824945 (2024)