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Hawkes, Safety and Efficacy of Glucagon-Like Peptide-1 Receptor Agonists in Children and Adolescents with Obesity: A Meta-Analysis

190 In general, cyanopyrrolidines such as saxagliptin are competitive inhibitors rather than noncompetitive inhibitors of DPP-IV enzymatic activity since they form reversible covalent bonds with serine residue 630 located within the enzyme's active site

doi: 10.1186/s13075-019-1810-5

Interestingly, mating with males have been well-documented to impose significant physiological costs on hermaphrodites and to result in drastically shortened lifespan, known as male/mating-induced demise (MID) 57,58