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They are injections, they can be expensive if insurance doesn't cover them, and side effects like nausea are common during the first few weeks as your dose increases

In NOD mice, treatment with the DPP4 inhibitor MK0431 prolonged the survival of islet grafts and reduced CD4+ T cell migration into the pancreas through the cAMP/PKA/Rac1 activation pathway
Serious adverse events and complications of these medications may include Gastroparesis (paralysis of the stomach), NAION vision loss, Ileus, Pancreatitis, Wernickes Encephalopathy, Bowel obstruction (blocked intestine), Malnutrition requiring hospitalization, and Pulmonary aspiration while under anesthesia or during surgery

While it can be a key component of a comprehensive weight loss plan, lifestyle change remains the foundation of sustainable weight loss
