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Liraglutide prevents cellular senescence in human retinal endothelial cells (HRECs) mediated by SIRT1: an implication in diabetes retinopathy

Last reviewed: May 12, 2026 Last updated: May 12, 2026 Written by: Jay Hastings , CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

Pharmaceutical GLP-1 agonists produce sustained receptor activation at levels far exceeding what natural GLP-1 achieves, even after meals

Their propensity-weighted analysis showed an extraordinary increased risk of increased RGC in the semaglutide users, with an OR of 37 [95% CI: 16.599.3]