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Butyrate possesses unique cell-signalling properties which have shown effects of decreasing insulin resistance in humans, increasing GLP1 production by intestinal cells & the liver, while also sensitizing our body to the effects of GLP-1 [3]
Regarding renal effects, the evidence of SGLT2is in preventing kidney failure is more abundant than for GLP-1RAs, which showed a beneficial effect on albuminuria but not on hard kidney endpoints
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