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Sex Differences in Response to Treatment with Glucagon-like Peptide 1 Receptor Agonists: Opportunities for a Tailored Approach to Diabetes and Obesity Care
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The activation of GLP-1R by Ex-4 in the ventral hippocampal formation induces hypophagia and reduces body weight in rats, through a specific reduction in meal size with no effect on meal frequency by mechanisms other than nausea [260]

Other GLP-1R/GIPR co-agonists such as Cpd86 (Eli Lilly), ZP-DI-70 (Zealand) and NN9709/MAR709 (Novo Nordisk/Marcadia) have also been designed and tested in preclinical models of obesity and subsequently advanced to clinical trials (Table 1)