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doi: 10.1158/1078-0432.CCR-21-0715 [DOI] [PMC free article] [PubMed] [Google Scholar] 136.Ishiguro N, Maeda K, Kishimoto W, et al

The potency of semaglutide was first confirmed in 2021 in The New England Journal of Medicine resulting in 14.9% weight loss compared to 2.4% placebo in 1961 subjects over 68 weeks

This is a real, biologically grounded effect, not just motivation

Yes, with careful evaluation
