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However, most effects on body weight are modest and tend to range between 2 to 4% body weight reduction (reviewed in Davidson, GLP-1R agonism in combination with the adjustable gastric band Bariatric surgery is by far the most effective therapy for weight loss reduction and improvements in glucose metabolism (Pories, 2008)

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Women with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2 (MEN2) should discuss their individual risk with a specialist before using any agent in this class, as the clinical significance in humans remains uncertain