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Phase 1: initiation and early escalation (weeks 1 to 8) During the first weeks, heart rate changes are generally minimal at starting doses
In these patients, mean eGFR was 63 mL/min/1.73 m
The peptides referenced are research compounds and are not FDA-approved for the uses discussed
The MHRA requires all women of childbearing potential taking topiramate to be enrolled in the UK Pregnancy Prevention Programme, which mandates highly effective contraception and regular counselling
