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10.1136/bmjopen-2023-083550 BMJ Open

Another trial demonstrated a significant reduction in body weight with the use of semaglutide, with subjects losing up to 14.9% of their initial body weight over a period of 68 weeks

Nuclear factor kappa B (NF-B), NH2-terminal Jun kinases, and p53 MAPK are transcriptionally regulated pathways that have been considered one of the most important stress-signaling pathways, and oxidative stress plays a role in the development of type 2 diabetes mellitus through their involvement (14)