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[Google Scholar] [17].Fernndez-Ruiz I, SELECT shows cardiovascular risk reduction with weight-loss drug semaglutide in people without diabetes, Nature Reviews Cardiology (2023)

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Maintaining weight loss after tirzepatide requires deliberate strategies: established exercise habits, protein-prioritized nutrition, and in some cases, transitioning to a lower maintenance dose rather than stopping completely

This is often called a plateau and typically is not true medication resistance