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Change Your Life Today For Only $249/month Questions and Answers: How Long Does A Vial of Semaglutide Last A vial of semaglutide typically lasts 30 days after it has been opened, assuming it is stored properly in a refrigerator at a temperature of 36F to 46F (2C to 8C)

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This happens because your body adapts to lower calorie intake, energy needs decrease, and factors like digestion, sleep, stress, and microbiome health start to play a bigger role in metabolic response

The STEP 2 trial in participants with type 2 diabetes showed 9.6% weight loss