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Description
Non-injectable treatment formats are becoming a strategic entry point for wider patient adoption, particularly for patients who are hesitant to start injectable GLP-1 therapies or may struggle with long-term injection adherence, storage requirements, and administration fatigue
29,33,34 Complexities When Investigating the Causal Association Between GLP-1 RA Therapy and Thyroid Cancer The investigation of the causal association between GLP-1 RA therapy and neoplasm is complex as it requires consideration of multiple factors such as biological interactions (e.g., the potential effects of type 2 diabetes and obesity, weight loss, and glucose reduction on cancer risk), direct biological effects (e.g., potential trophic effects and other direct effects of GLP-1 RA, personal susceptibility to thyroid cancer), and factors associated with the conduct of clinical studies (e.g., selection bias, detection bias, length of follow-up)

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Another factor to consider is gastrointestinal tolerance