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In addition to this, the trigeminal perception of the peripheral and somatosensory systems can be guided through transient receptor potential channels (TRP), that are cation selective (mainly calcium) and modulated by calmodulin, phospho-lipases, and kinases (31)
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Under certain conditions, such as sustained membrane depolarization and a reduction in GLP-1 concentration to picomolar levels, there can be a switch between Gs and Gq pathways [14]
