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Preclinical research shows that bitter compounds act through an extracellular odorant binding protein to inhibit sweet-responsive neurons and block the response to sweet taste, 9 making bitter herbs an important therapeutic tool in modifying dietary choices

doi: 10.1016/j.smrv.2016.12.003

This cycle reinforces itself over time

Although EECs might sense nutrients via activation of specific GPCRs on the apical side, where they are in direct contact with the luminal environment, elegantly performed ex vivo and in vitro studies suggest that many nutrients, including fatty acids, may be detected on the basolateral surface 17,93,94