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GLP-1 medications may cause gastrointestinal symptoms, such as: Nausea Vomiting Diarrhea Constipation These tend to happen most often when increasing doses, but usually improve over time
To explore the broader impact of semaglutide on systemic pathophysiology, we performed ultra-sensitive proteomics (NULISA) on plasma samples from both groups of rats (n=12/group)

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Long-acting injectable semaglutide microcapsules were quantified by HPLC using a system containing a C8 column and a mixture of acetonitrile, water, and 0.1% trifluoroacetic acid [69]
