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Reduced fluid intake, nausea, or vomiting can lead to electrolyte imbalances, including: Sodium Potassium Chloride Electrolyte shifts can worsen fatigue, dizziness, muscle cramps, and kidney stress
Academic Press

In several organ systems, at least part of the benefit appears to occur before major weight loss or independent of the number on the scale
However, the market is now diversifying beyond incretin pathways toward alternative mechanisms such as CB1 antagonists, MC4R agonists, and myostatin/activin inhibitors
