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These disorders can be associated with insulin resistance, hyperglycemia-induced damage, oxidative stress, astrocyte abnormalities, and mitochondrial dysfunction, resulting in insufficient energy supply, altered synaptic plasticity, death of neuronal cells, as well as functional and structural damage to reward networks

Funding Statement This research was funded by the Ministry of Science and Technology (Taiwan) under grant 110-2314-B-281-007-MY3 and Cathay research grant CGH-MR-A10905 and CGH-MR-A11311

There have been cases reported where, if one relies solely on the drug without changing diet and exercise habits, weight increases beyond the original level after discontinuation

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