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Studies in rodents and primates have signaled that GLP-1 agonists may drive a reduction in intake of alcohol and drugs of abuse, and clinical trials have been initiated to investigate whether preclinical findings can be translated to humans

However, this could reflect differences in the TMD of GLP-1R and GCGR and their intrinsic ability to activate G protein in the absence of agonist, independent of the ECD

Other GLP-1 drugs also affect oral contraceptives to varying degrees

Genetic PCA was used to capture the underlying population structure and define genetic ancestry more precisely, categorizing participants into groups such as European, South Asian, African, East Asian and other ancestries