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The SELECT trial, completed in 2023 with over 17,600 participants, showed a 20% reduction in cardiovascular events in patients with established cardiovascular disease and overweight or obesity without diabetes
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Moreover, potassium (K+) channels expressed in pancreatic -cells and peripheral insulin-sensitive tissues, which play a key role in glucose metabolism, are intensely modulated by carvedilol, establishing a link between K+ channels and the drugs effects on glucose control
