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The TRIUMPH-4 Phase 3 data provides the most current safety information: Nausea: 38.1% (9 mg) to 43.2% (12 mg) versus 10.7% placebo Diarrhea: 34.7% (9 mg) to 33.1% (12 mg) versus 13.4% placebo Constipation: 21.8% (9 mg) to 25.0% (12 mg) versus 8.7% placebo Vomiting: 20.4% (9 mg) to 20.9% (12 mg) versus 0% placebo Decreased appetite: 19.0% (9 mg) to 18.2% (12 mg) versus 9.4% placebo The pattern is clear
The study defined mental illness as a combination of hospitalization due to mental disorder or self-harm, sick leave for psychiatric reasons, or suicide
In patients on basal insulin who require additional prandial control, GLP-1RAs are again positioned ahead of DPP-4 inhibitors in the AACE algorithm 51
Risk of suicide and self-harm is increased after bariatric surgery-a systematic review and meta-analysis
