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Introduction What is orforglipron

268 The latter includes both central homeostatic (energy-intake-focused) and non-homeostatic (reward-focused) regulation of food consumption in the hypothalamus and nucleus of the solitary tract, 268-271 influenced by a relatively small amount of GLP-1 that crosses the blood-brain barrier and, more notably, GLP-1 modulation of vagal afferent neurons

Mol Metab (2013) 3(3):24151

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