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Novo Nordisk) oral tablets are now available in sufficient quantities to support initiation of GLP-1 RA treatment in type 2 diabetes mellitus (T2DM) and can be prescribed in line with National Institute for Health and Care Excellence (NICE) guidance

However, the trial's low event rate and reliance on serum creatinine to assess eGFR, which may be influenced by muscle mass changes, limit the robustness of its conclusions

Most incretin-based compounds target only the first two the addition of glucagon receptor agonism distinguishes this compound in research settings

Regular moderate exercise supports hormonal balance, though excessive exercise combined with rapid weight loss can exacerbate menstrual irregularities