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To a large extent, these changes are also characteristic of metabolic syndrome, which affects approximately 25% of the worlds adult population and is associated with insulin resistance, hypertension, dyslipidemia and obesity, factors that increasingly lead to cognitive impairment and brain atrophy

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Tirzepatide (Zepbound) was also recently FDA-approved for weight loss, with studies showing it can help patients lose up to 20% of their body weight

Abruptly stopping creates a sharp drop in appetite suppression, making the first 24 weeks the highest-risk period for overeating and rapid weight gain