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Tirzepatide-Specific Considerations Tirzepatide appears to have slightly higher rates of GI side effects compared to Semaglutide in head-to-head trials, though discontinuation rates remain relatively low
For example, GIP stimulates insulin secretion but also increases GCG levels 7,8 , while the latter has a parallel role in elevating energy expenditure and blood glucose 9
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All interview study participants who had received retatrutide lost weight during the trial
