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Histamine intolerance results from impaired histamine breakdown by diamine oxidase (DAO), causing symptoms such as headaches, flushing, and gastrointestinal disturbances
[DOI] [PMC free article] [PubMed] [Google Scholar] 37.Salvoza N., Giraudi P., Gazzin S., et al

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In toxin-based models, upregulation of GLP-1/IGF-1 signaling by 4-hydroxyisoleucine improved motor behavior, preserved myelin, and reduced apoptosis (166)