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Its fresh contribution lies in unifying neuro-inflammatory, glial, mitochondrial, and barrier mechanisms across multiple ocular diseases, critically contextualizing clinical safety signals against mechanistic plausibility and study quality, and highlighting gaps addressed by ongoing trials (e.g

The association between SGLT2 inhibitors and better iron absorption at baseline is of special interest, since this drug class is known to promote erythropoiesis and, therefore, may influence better iron utilization and absorption

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