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In the intestine, if HDAC is overexpressed, the balance of gene expression is disrupted and cell proliferation is abnormal, which eventually leads to tumorigenesis ( In particular, SCFAs contribute significantly in the fight against intestinal inflammation by promoting T reg cells differentiation through the inhibition of HDACs

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There is a need for more phase III studies to provide sufficient clinical evidence for the effectiveness of retatrutide, as current evidence is limited to phase II studies and has yet to prove its worth in a larger population

[DOI] [PMC free article] [PubMed] [Google Scholar] 140.Chiu I.M., Morimoto E.T.A., Goodarzi H., Liao J.T., OKeeffe S., Phatnani H.P., Muratet M., Carroll M.C., Levy S., Tavazoie S., et al