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The US Food and Drug Administration issued a warning Tuesday about compounded versions of the drug semaglutide, which is approved for treatment of diabetes and excess weight.

Additionally, it induces changes in the cervical mucus, making it thicker and less permeable to sperm

After a 4-week run-in period in which participants were treated with diet and exercise alone, those who fulfilled the randomisation criteria were randomised (1:1:1:1) using a web-based randomisation system to receive once-daily oral semaglutide 3 mg, 7 mg or 14 mg or placebo for 26 weeks (using a 4-week dose-escalation regimen for the higher doses)