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I suspect this is from the glucagon agonism of the drug as glucagon stimulates the formation of extra bile acids/bile salts in the liver which can be very irritating to the intestinal lining causing diarrhea
Around 1 in 10 people carry variants in the PAM gene that can interfere with the activation of hormones, including GLP-1
Efficacy and safety of Ipragliflozin as an add-on therapy to sitagliptin and Metformin in Korean patients with inadequately controlled type 2 diabetes mellitus: a randomized controlled trial
Management of hypogonadism in adolescent girls and adult women with Prader-Willi syndrome
