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Large outcome trials LEADER, SUSTAIN-6, REWIND, SELECT, and the more recent SOUL trial, which included 788 Indian patients have shown that certain GLP-1 drugs meaningfully reduce heart attacks, strokes, and cardiovascular death [5][6], with a 26% reduction in heart attacks among Asian participants in SOUL

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doi: 10.1097/CM9.0000000000002060 55 BrownEHeerspinkHJLCuthbertsonDJWildingJPH

This limitation prevents us from differentiating between low initiation rates due to physician practices versus patient-related barriers such as cost, which is particularly relevant given the high out-of-pocket expenses for these medications in Poland