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The side effects of semaglutide include : Nausea Vomiting Diarrhea Abdominal pain Headache Fatigue Indigestion Dizziness Bloating Belching Flatulence Hypoglycemia (in people with type 2 diabetes) Stomach flu Gastroesophageal reflux disease (GERD) Cold-like symptoms The above side effects were reported by at least 5% of people in clinical trials

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In two recent systematic reviews and meta-analyses, no link between GLP-1RA use (for obesity and/or T2D) and increased suicidal ideation was identified, but there was substantial heterogeneity between studies, particularly regarding the definition of suicidal ideation (102, 103)